مکتبة تیجان معیاروصف الجهات الأرشیفیة المکود (EAG 2012): تعریب موجز

External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor

The Ether-a-go-go (EAG) superfamily of voltage-gated K(+) channels consists of three functionally distinct gene families (Eag, Elk, and Erg) encoding a diverse set of low-threshold K(+) currents that regulate excitability in neurons and muscle. Previous studies indicate that external acidification inhibits activation of three EAG superfamily K(+) channels, Kv10.1 (Eag1), Kv11.1 (Erg1), and Kv12...

موجز، دشوار، غربی

Oncogenic potential of EAG K(+) channels.

We have investigated the possible implication of the cell cycle-regulated K(+) channel ether à go-go (EAG) in cell proliferation and transformation. We show that transfection of EAG into mammalian cells confers a transformed phenotype. In addition, human EAG mRNA is detected in several somatic cancer cell lines, despite being preferentially expressed in brain among normal tissues. Inhibition of...

A MAGUK Enhances EAG Potassium Channel Function

Adaptor proteins, by bringing together kinases and other effectors, form a submembrane scaffold of signaling molecules. One such adaptor, Drosophila Camguk (CMG), is a member of the membrane-associated guanylate kinase family and associates with calciumand calmodulin-dependent protein kinase II (CaMKII). This week, Marble et al. describe a signaling complex including CMG, CaMKII, and the Ether-...

ابن سینا و فلک محدد الجهات

نظام هیئت به طلمیوسی بر مبنای اعتقاد به وجود هشت فلک شکل گرفته بود که محاسبات علم هیئت و نجوم مورداستفاده قرار می گرفت فیلسوفان نخستین مسلمان ( فارابی و ابن سینا) فلک دیگری بر این مجموعه افزودند که بر آن نام محدد الجهات نهادند براهین فیلسوفان در بحث افلاک جمله مربوط به این فلک است و در اثبات وجود سایر افلاک برهانی اقامه نکرده اند به نظر می رسد که ابطال نظام بطلمیوسی خللی به وجود این فلک وارد نم...